 FRIDAY, Aug. 28 (HealthDay News) -- Moderate daily exercise prevents obesity in rats born to undernourished mothers by activating pathways in skeletal muscle that enhance metabolic flexibility, according to a study in the September issue of Endocrinology.
Korinna Huber, Ph.D., from the University of Veterinary Medicine in Hannover, Germany, and colleagues fed pregnant rats chow ad libitum or undernourished them (30 percent of ad libitum intake) to produce normal offspring or intrauterine growth restriction (IUGR) offspring. Previous work had shown that IUGR rats have a higher preference for voluntary exercise, and moderate daily exercise prevented the obesity that normally develops in adult IUGR rats.
The researchers found that red muscle from IUGR rats had a higher oxidative capacity that was not due to increased fatty acid oxidation. White muscle from exercised IUGR rats had increased anaerobic utilization of glucose, while stimulation of a lactate shuttle prevented exercise-induced lactate accumulation.
"This enhanced metabolic flexibility in IUGR offspring may facilitate muscle contractile performance and therefore support moderate daily exercise for effective obesity prevention," Huber and colleagues conclude.
Abstract
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